The reduced GLT-1 expression seen in ALS, schizophrenia, mood and anxiety disorders, Alzheimer's disease, brain injury, glaucoma, HIV-associated dementia, and addition is regulated at two levels, transcriptional and during mRNA maturation (splicing) [132]; for example, in ALS an abnormal splicing of Glu transporters mRNA which results in truncated mRNA species has been demonstrated [133]. The gene discussed is SLC1A2; the disease is amyotrophic lateral sclerosis.