Compared to WT BM-transplanted Fah−/− mice that remained healthy after NTBC withdrawal and exhibited a high survival rate, GKO BM-transplanted Fah−/− mice showed marked weight loss and died within 6 months after NTBC withdrawal (Fig. 4a,b); these mice also displayed severe liver dysfunction, with increased total serum bilirubin levels and liver pathology (Fig. 4c,d). Here, FAH is linked to Decreased liver function.