MAPT and Alzheimer disease: Therefore, double phosphorylated tau neoepitopes (pSer202/pThr205, pThr212/pSer214, pThr231/pSer235), were chosen representing an early (pThr231/pSer235), an intermediate (pThr212/pSer214) and a late (pSer202/pThr205) phosphorylation event in AD [29,30].