FOXO3 and breast cancer: Previous studies demonstrated that FOXK2 cross-talks with the tumour suppressor FOXO3a to regulate cell proliferation and survival.20 Given that FOXO3a has been shown to mediate the cytostatic and cytotoxic functions of taxanes and anthracyclines,11, 12, 15, 21 together these findings led us to hypothesize that FOXK2 might target FOXO3a expression to induce breast cancer cell proliferation arrest and cell death in response to these conventional anticancer chemotherapeutics.