Indeed, recent results implicated that FOXO1 had a tumor-suppressing role in OS.23, 24, 25 Especially, FOXO1 was shown to be targeted by MiR-135b and expressed at low levels in OS tissues comparing to paired adjacent non-neoplastic bone; forced expression of FOXO1 inhibited OS cell proliferation and invasion.25 Here, FOXO1 is linked to neoplasm.