VEGFA and neoplasm: Moreover, vascular endothelial growth factor gene amplification and vascular endothelial growth factor expression have been shown to be associated with poor prognosis7, 8 and pulmonary metastasis.8 Platelet-derived growth factor and its receptor are expressed in most OS tumors and correlate with inferior event-free survival.9 These growth factors are potent mitogens for tumor cells and act by autocrine or paracrine mechanisms through modulation of multiple oncogenic signaling pathways, including suppression of FOXO transcription factors via the PI3K/AKT pathway.10