The association of integrin-β1 with EGFR is well known.33 Integrin-α2β1 associates with EGFR, and these protein interactions increase EGFR phosphorylation.34 Thus, we next investigated whether integrin-β1 and integrin-α2 controlled MMP-7 expression on stiffer substrates in colorectal cancer. The gene discussed is MMP7; the disease is colorectal cancer.