In this context, interest has focused on the N-glycan biosynthesis of glycoproteins and, in particular, branching enzymes, such as N-acetylglucosaminyltransferase III (GnT-III), GnT-IV, GnT-V and a1-6 fucosyl- transferase (a1-6FucT) [124,125], that can regulate the further processing of the N-glycan structures, which play a pivotal role in tumor development, metastasis and invasion. This evidence concerns the gene MGAT3 and neoplasm.