Single-nucleotide polymorphisms in IL-1β (−511C/T), IL-10 (−592C/A), TNF-α (−308G/A, −238G/A), TGF-β1 (−509C/T) and CTLA4 (+49A/G) were assessed in a South Indian population of 181 patients with alcoholic cirrhosis and 110 controls. The gene discussed is TNF; the disease is alcoholic liver cirrhosis.