The presence of the CXCL1 rs4047 A allele was higher among patients with alcoholic cirrhosis (65.3%) than among alcoholic controls (54.8%) (OR 1.55 95% CI 1.025–2.350 p = 0.04) in a large sample of 458 patients with alcoholic cirrhosis (170 with HCC), 115 alcoholics without liver disease and 342 healthy controls. This evidence concerns the gene CXCL1 and alcoholic liver cirrhosis.