In NIH3T3 cells, bFGF stimulates GLI1-luciferase activity in a MEK-1-dependent manner [40], but in medulloblastoma, FGF is shown as a canonical shh signaling inhibitor in an ERK dependent manner [46], indicating a significant effect of cellular context in the output of signal interaction (see more in Figure 1). This evidence concerns the gene GLI1 and medulloblastoma.