Malatesta et al. reported that p300/CREB-binding protein-associated factor (PCAF), a histone acetyltransferase, interacts with GLI1 and is recruited to the promoter of GLI1 responsive gene leading to H3K9 acetylation of Hh target gene promoters and their activation in medulloblastoma and glioblastoma cells, and PCAF downregulation in these cells leads to decreased proliferation and increased apoptosis [65]. Here, GLI1 is linked to medulloblastoma.