In contrast, several mRNAs encoding known anti-tumor immune mediators or reflective of anti-tumor type I immunity, including IFN-γ, T-bet, CXCL10, and IL-12 (Vesely et al., 2011), were markedly increased in Ptgs2−/− melanomas (Figures 2B and 2D). This evidence concerns the gene IFNG and melanoma.