Mediators secreted by these cells that directly or indirectly promote cancer cell growth include cytokines, chemokines, and growth factors, such as VEGF-A, CSFs, IL-1, IL-6, IL-8, or CXCL1 (Balkwill et al., 2005; Coussens et al., 2013). The gene discussed is CXCL1; the disease is cancer.