To assess cancers other than melanoma and use mouse strains other than C57BL/6, we chose CT26 colorectal and 4T1 breast cancer cell lines that grow in BALB/c mice and also display constitutively active RAS/RAF/MEK/ERK signaling (Castle et al., 2014; Phan et al., 2013) and produce PGE2 (Figures 5A and S4). This evidence concerns the gene MAP2K7 and breast cancer.