We report that high LAPTM4B expression is indicative of poor survival in LUAD and that LAPTM4B protects cells from starvation-induced stress, promotes cellular autophagy and activates NRF2-mediated cell stress response and pathway suggesting that LAPTM4B may be a viable target for NSCLC therapy. The gene discussed is LAPTM4B; the disease is non-small cell lung carcinoma.