In addition, A34 (a small peptide derived from p53 linker) binds directly to iASPP and competitively inhibits the iASPP-p53 interaction in human tumor cells [88], causing WT p53-mediated transcriptional activation of Bax and PUMA and tumor cell apoptosis in vitro and in vivo [88]. Here, TP53 is linked to neoplasm.