Treatment with the anti-IL-6 antibody siltuximab inhibited IL-6 signaling, STAT3 phosphorylation, tumor growth and macrophage infiltration in ovarian cancer xenografts, and siltuximab treatment in a phase I clinical trial in ovarian cancer patients correlated with reduced plasma levels of IL-6-regulated chemokines [81]. The gene discussed is STAT3; the disease is ovarian cancer.