Prostate-specific membrane antigen (PSMA) is another endothelial cell surface molecule that is upregulated on prostate tumor cells as well as on tumor endothelial cells of the stroma of breast, renal cell, bladder, non-small cell lung, prostate and rectal carcinoma, glioblastoma multiforme and melanoma [97]. This evidence concerns the gene FOLH1 and rectal carcinoma.