Homocysteine, for example, has been shown to exert multiple effects that may contribute to cognitive decline, such as increasing tau phosphorylation via a post-translational modification-mediated reduction in protein phosphatase 2A (PP2A) function [14], glutamate receptor dysfunction, neuronal apoptosis induction, endoplasmic reticulum stress, DNA methylation, mitochondrial dysfunction, vascular damage, and oxidative stress [15]. Here, MAPT is linked to Mental deterioration.