Although macrophages play a key contributory role in liver fibrosis by releasing pro-fibrogenic cytokines, promoting the survival of activated hepatic stellate cells (HSCs) [46] and promoting HSC migration through chemokines such as CCL2 [47], they also promote fibrosis resolution through enhanced extracellular matrix degradation via increased MMP expression [3]. The gene discussed is CCL2; the disease is Hepatic fibrosis.