ALK and non-small cell lung carcinoma: In addition, with regard to the cumulative risk of IC metastasis in ALK+ NSCLC pts, Rangachari and colleagues reported that the incidence of BM in ALK-rearranged pts at 1, 2, and 3 years from the initial diagnosis was 23.8, 45.5, and 58.4 %, respectively [15].