By adding the functional CCL5 recombinant protein (rCCL5) directly into the culture of various PCa cell lines, we found increased HIF2α expression in PCa cells (Figure 3a), and blocking CCL5 (via CCL5 neutralizing antibody) suppressed the BM-MSCs induced HIF2α expression (Figure 3b). This evidence concerns the gene CCL5 and posterior cortical atrophy.