The findings that AR in individual cells within the TME might play differential roles (positive vs negative roles) could further complicate the androgen/AR signaling in PCa progression [7–13] and raised special questions about the current androgen deprivation therapy (ADT), which systematically suppresses/reduces androgen from binding to AR in every cell, to suppress the progression of PCa, a disease that has become the most prevalent cancer among males in United States with the 2nd highest mortality rate. This evidence concerns the gene AR and cancer.