(Figure 4c) Next, we examined the expression of PHDs, members of the iron- and 2-oxoglutarate-dependent dioxygenase enzyme family [27], in PCa cells upon BM-MSCs co-culture, as early studies suggested the PHDs can catalyze hydroxylation of HIF2α and then promote its binding to VHL, a E3-ligase of the HIF2α [28]. Here, VHL is linked to posterior cortical atrophy.