Interferon-gamma (IFN γ), tumor necrosis factor (TNF), Interleukin 10 (IL-10), IL-17, IL-4, C–C chemokine RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted), matrix metalloproteinases 8 (MMP8s) and tissue inhibitor of metalloproteinases 1 (TIMP1) have been linked to disease severity in malaria-infected individuals [9–16]. The gene discussed is TNF; the disease is malaria.