However, it is also true that the prognostic roles of FOXP3 remain controversial; for instance, breast cancers with FOXP3+ TIL have been reported to be less sensitive to cytotoxic chemotherapy and have a worse prognosis [17, 20], but others reported that those with FOXP3+ TIL have a better prognosis [21, 22]. The gene discussed is FOXP3; the disease is breast cancer.