AFP and hepatocellular carcinoma: A large multi-centre study in America involving 419 HCC cases and 417 cirrhosis controls showed that for Early Stage HCC, AFP had a better performance/accuracy than DCP but when intermediate- advanced stage HCC (similar to most cases in our study) were compared, then DCP had the better performance/accuracy (AUROC = 0.89for DCP against 0.84 for AFP) [31].