At physiological ligand concentrations, no competition between VEGF and Semaphorins for Neuropilin binding was observed; instead, the level of VEGF and Semaphorin signaling complexes were independent, with some metastatic tumors exhibiting elevated VEGFA receptor binding, others exhibiting reduced Semaphorin receptor binding, and some exhibiting both. The gene discussed is VEGFA; the disease is metastatic neoplasm.