Using the TCGA RNA-Seq dataset, we found that while two key pro-angiogenic ligands, VEGFA and PGF, were up-regulated in renal cell carcinoma, they were down-regulated in primary prostate adenocarcinoma (Fig. 1a, b for prostate, Fig. 1e, f for kidney). The gene discussed is VEGFA; the disease is hereditary clear cell renal cell carcinoma.