Moderate hyperinsulinemia (with euglycemia) induced by IV insulin infusion in healthy, older adults increased Aβ1-42 levels in blood plasma and CSF, as well as increasing CSF levels of certain pro-inflammatory cytokines: interleukins 1a, 1b, and 6 (IL-1a, IL-1b, IL-6,) and TNF-α [70]. The gene discussed is INS; the disease is Hyperinsulinemia.