ACHE and Alzheimer disease: The drugs currently available on the US market and approved for the treatment of Alzheimer’s disease, such as acetylcholinesterase inhibitors (e.g., donezepil, rivastigmine) and NMDA-receptor antagonists (memantine), cannot reverse or stop AD pathology; at best, they slow the progression of cognitive and behavioral symptoms, but their effectiveness varies across individuals and can decrease over time within the same individual.