Of the thirteen genes and the rRNA and tRNA subunits in the mitochondrial genome, four genes were associated with CRC at a P value < 0.05: mitochondrially encoded NADH dehydrogenase 2 (MT-ND2) (P = 1.0x 10–3) and mitochondrially encoded NADH dehydrogenase 4 (MT-ND4) (P = 0.015) in complex I; mitochondrially encoded cytochrome b (MT-CYB) (P = 0.027) in complex III; and mitochondrially encoded ATP synthase 8 (MT-ATP8) (P = 0.036) in Complex V. The MT-ND2 gene remained significantly associated with CRC after multiple correction (q = 0.015; Table 2). This evidence concerns the gene MT-ND4 and colorectal carcinoma.