We observed slight but non-significant differences in phosphorylation of Akt between NG2 siRNA and control siRNA treated glioma cells under stress conditions where NG2 expression confers better survival (data not shown), but we observed that in GBM cells treated with the specific OMI inhibitor UCF the protective effect of NG2 is eliminated. This evidence concerns the gene HTRA2 and glioblastoma.