Quantification of the number of microglial cells adjacent to grafted NPC regions supported the qualitative impressions indicating that specifically SHH played a role in inhibiting the response of endogenous CD11b+ (p<0.001, F7, 112 = 81.79, one way ANOVA) and CD68+ (p<0.001, F5, 84 = 80.74, one way ANOVA) cells after transplantation (Fig 6Y and 6Z). Here, CD68 is linked to nasopharyngeal carcinoma.