We detected that KPT-185 induced reductions of total- and phosphoactivated-HSF1 along with its targets PlM2, HSP70, phospho-HSP90 and EEF1A1; the absence of effects on HSF1 mRNA levels indicated that XPO1 inhibition repressed HSF1 translation but not transcription, through mechanisms that remain to be elucidated in MCL cells. This evidence concerns the gene HSF1 and mantle cell lymphoma.