KPT-185 further downregulated phosphorylation levels of the mTOR substrates ribosomal protein S6 kinase (S6K) and/or eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) in most cases of tested MCL cells (Fig 5C). The gene discussed is MTOR; the disease is mantle cell lymphoma.