The p53 status-independent transcriptional induction of PUMA by KPT-185 indicates the role of additional transcriptional factors, such as an XPO1 cargo FOXO3a that is responsible for the upregulation of PUMA [44], or NF-κB, whose blockade by KPT-SINEs induced p53-independent depletion of MCL cells [13, 45]. The gene discussed is XPO1; the disease is mantle cell lymphoma.