XPO1 and mantle cell lymphoma: We detected that KPT-185 induced reductions of total- and phosphoactivated-HSF1 along with its targets PlM2, HSP70, phospho-HSP90 and EEF1A1; the absence of effects on HSF1 mRNA levels indicated that XPO1 inhibition repressed HSF1 translation but not transcription, through mechanisms that remain to be elucidated in MCL cells.