PIM1 and mantle cell lymphoma: Immunoblot analysis detected KPT-185 induced downregulation of c-Myc and PIM1 and increase of p27KIP, a cyclin dependent kinase (CDK) inhibitor in all tested MCL cell lines except Jeko-1 which showed only minimal changes (Fig 5B), suggesting that XPO1 inhibition by KPT-185 may affect oncogenic c-Myc and PIM1 as well as cyclin D1 functions to different degrees in MCL cells.