PIM1 and mantle cell lymphoma: We demonstrated that XPO1 inhibition by KPT-185 exhibited single-agent anti-proliferative activities against MCL cells via inhibition of multiple factors: ribosomal biogenesis and protein synthesis, the transcription factor HSF1, and the nuclear export of oncogenic mRNAs, including cyclin D1, c-Myc and PIM1 (Fig 6).