Likewise, the frequency of “total IFN-γ+ CD8+ T cells” (Figure 5(b)), “total IL-2+ CD8+ T cells” (Figure 5(c)), and “total TNF-α+ CD8+ T cells” (Figure 5(d)) was significantly higher in active TB patients compared to the other 2 groups of patients. The gene discussed is TNF; the disease is tuberculosis.