The frequencies of “total IFN-γ+ CD4+ T cells” and “total IL-2+ CD4+ T cells” were higher in LTBI patients compared to those with active TB and healthy controls, although these differences attained statistical significance only between Mtb-infected (active TB and LTBI) and healthy subjects (P = 0.0014 for IFN-γ; P = 0.0001 for IL-2 by Kruskal-Wallis test) (Figures 2(c) and 2(d)). This evidence concerns the gene CD4 and tuberculosis.