SNAI1 and cancer: This response leads to the activation of Snail1, that along with the upregulation of other genes responsible for loss of adherence, represents a signal promoting cell migration and metastasis (present work, Figure 4 adherens junction); (iii) miR-34 downregulation contributes to the abnormal expression of Snail1, which is normally antagonized by miR-34 and whose pathological expression has been linked to cancer cell epithelial-mesenchymal transition; (iv) miR-200 downregulation contributes to the epithelial-mesenchymal transition as well.