The expression and prognostic role of hERG1 was investigated in ESCC by means of IHC and RT-PCR [26]. KCNH2 gene and hERG1 protein were found to be expressed in a high percentage of ESCC samples (with respect to normal esophageal squamous epithelium) but no correlations emerged with clinicopathological features. Here, KCNH2 is linked to esophageal squamous cell carcinoma.