PCA3 and posterior cortical atrophy: In the most recently published prospective multicenter study (n = 443) [48], both PCA3 and TMPRSS2:ERG had independent additional predictive value over the European Randomised Study of Screening for Prostate Cancer risk calculator (ERSPC-RC) parameters for predicting PCa in multivariate analyses (OR, 3.64; P < 0.001 and OR, 3.28; P = 0.002, resp).