The aim of the work was to evaluate the significance of common genetic variation in four genes involved in DNA double-strand break repair via homologous recombination, that is, RAD51, RAD51B, XRCC2, and XRCC3, in prostate cancer susceptibility, tagging six most widely studied single nucleotide polymorphisms (SNPs) in these genes. This evidence concerns the gene RAD51B and prostate cancer.