XRCC3 and Familial prostate cancer: The aim of the work was to evaluate the significance of common genetic variation in four genes involved in DNA double-strand break repair via homologous recombination, that is, RAD51, RAD51B, XRCC2, and XRCC3, in prostate cancer susceptibility, tagging six most widely studied single nucleotide polymorphisms (SNPs) in these genes.