PPARA and fatty liver disease: Moreover, given the growing interest in the roles of lipotoxicity, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction as mediators of steatohepatitis progression [19,21,36,37], it was of interest to determine if the therapeutic effects of PPAR agonists were associated with resolution of hepatic steatosis, ER morphology, and mitochondrial cytopathy.