The reductions in 4-HNE correspond with the reduced levels of steatosis (histology, Nile Red, EM) and restoration of mitochondrial structure (reflecting improved metabolism) correspond with PPAR-δ agonist-mediated reductions in lipid peroxidation (4-HNE), which itself could drive hepatocellular injury, turnover, and degeneration. This evidence concerns the gene PPARD and steatosis.