Yang et al. failed to demonstrate carbamazepine-modified peptides presented by HLA-B*15:02, a known risk allele for carbamazepine-induced SJS/TEN in certain Asian populations [12], but detected HLA-B*15:02-specific peptides and carbamazepine alone, suggesting a non-covalent interaction [13]. This evidence concerns the gene HLA-B and toxic epidermal necrolysis.