It was described in studies that Rhubarb therapies could suppress production of lipid peroxides (LPO) [16], reduce content and activity of malondialdehyde (MDA) [25, 26, 33, 39], inhibit activity of myeloperoxidase (MPO) [25, 34], increase superoxide dismutase (SOD) [16, 24–26, 33, 39] activity, and upregulate catalase (CAT) and glutathione-peroxidase (GSH-Px) [39] activity in sepsis animals, indicating that Rhubarb might be able to reduce oxidative stress during sepsis. Here, SOD1 is linked to Sepsis.