LPS model is notable for the advantages of simple, reproducible, highly controlled, and standardized administration, while, at the same time, the disadvantages of it cannot be easily overlooked: early, high, and transient increases of inflammatory mediators through a TLR4-dependent pathway, different hemodynamic response from human sepsis, not being able to reflect all complex physiological responses in human sepsis, and variability in dose and administration route [53–57]. Here, TLR4 is linked to Sepsis.