ERBB4 and amyotrophic lateral sclerosis: Furthermore, the involvement of ErbB signaling in ALS was raised with the description of disrupted neuregulin-ErbB4 pathway signaling in presynaptic synapses of less resistant spinal cord motor neurons (Takahashi et al., 2013), but not in the resistant oculomotor neurons in human ALS (Gallart-Palau et al., 2014).