Conversely, Cdkn1a dysregulation was described in muscles of ALS mice (Gonzalez de Aguilar et al., 2008) and CDKN1A, a cyclin-dependent kinase inhibitor, interferes with satellite cell-induced myoplasticity in ALS skeletal muscles (Manzano et al., 2013). This evidence concerns the gene CDKN1A and amyotrophic lateral sclerosis.