The analyses of inflammatory markers revealed higher serum concentrations of TNF-α (P = 0.05), IL-6 (P < 0.001), CRP (P < 0.001), neutrophils (P < 0.001), and leukocytes (P < 0.001) in COPD patients when compared with controls. The gene discussed is TNF; the disease is chronic obstructive pulmonary disease.