NF-κB is activated in the synovial tissue from RA patients; both subunits p50 and p65 are located in the nuclei of the synovial macrophages, and the RA FLS and TNF-α and IL-1β induce a rapid NF-κB translocation in the RA FLS. The gene discussed is NFKB1; the disease is rheumatoid arthritis.