However, bearing in mind that the protective effect against arthritis of AIQ in the CIA model was mediated by a reduction of the autoimmune response [35], it is also possible to speculate that, in the future, PARP inhibitors will be developed that induce a strong diminution of the immune response, leading to the remission of RA and avoiding the need for chronic treatment. Here, PARP1 is linked to rheumatoid arthritis.