For leprosy reactions, the most common proinflammatory mediators were TNF-α (7 articles), IFN-γ (5 articles), IL-6 (4 articles), and IL-17 (3 articles), and the most common anti-inflammatory mediators were IL-4 (4 articles) and IL-10 (4 articles) (Table 1). This evidence concerns the gene TNF and leprosy.