On the one hand, high serum TNF-α levels were shown to be associated with the extent and severity of disease [82, 94] and with the clinical parameters of individuals with PDagG and CPD [42, 49, 70, 90, 91, 95–99]; on the other hand, Tokoro et al. [89] reported high serum TNF-α and IL-1β levels in gingivitis. This evidence concerns the gene TNF and gingivitis.