In studies of aggressive periodontitis (PDag) and chronic PD (CPD), 6 proinflammatory mediators (IL-1β, IL-6, IFN-γ, TNF-α, IL-17, and IL-12) and 2 common anti-inflammatory mediators (TGF-β and IL-4) were involved. The gene discussed is TNF; the disease is periodontitis, aggressive.