Therefore, we examined the levels of soluble TNF receptors (sTNFR-I and sTNFR-II), soluble IL-6 receptors (sIL6R, sgp130), adhesion molecules (sICAM-1, sVCAM-1), and inflammatory markers (CRP, SAA) in serum of T1D patients with and without DR. This evidence concerns the gene IL6R and type 1 diabetes mellitus.