We also detected depressed expression of miR-182 and perhaps miR-185 in human subjects exposed to high level of PM2.5 and overexpression of SLC30A1, SERPINB2 and AKR1C1, which we have first demonstrated to be target genes of miR-182 and/or miR-185, in human lung cancer compared with the corresponding normal lung tissues. The gene discussed is SERPINB2; the disease is lung cancer.