It is noteworthy that a potentiating effect of autophagy and ALK co-inhibition was still observed following ATG7 downregulation; 3) ALK inactivation combined with autophagy inhibition drove cells towards apoptotic/necrotic cell death; 4) combined crizotinib and chloroquine treatment strongly reduced ALK-positive Karpas-299 clonogenic survival, unequivocally proving that autophagy harbors cytoprotective functions [68], and impaired xenograft tumor growth. This evidence concerns the gene ALK and neoplasm.