ALK and anaplastic large cell lymphoma: Overall, these results indicate that ALK inactivation, either through pharmacological (crizotinib) or molecular approaches (ALK-targeted siRNA), induces an increase in the number of autophagosomes and autophagic flux in at least two of the most commonly used ALK-positive ALCL cell lines: Karpas-299 and SU-DHL-1.