We confirmed the loss of NPM-ALK autophosphorylation (data not shown) and the decreased viability of the ALCL cell lines (Supplemental Figure S2A and S2B) following treatment with crizotinib at either 500 nM for Karpas-299 cells (a concentration which corresponds to the plasmatic dose measured in patients being treated for ALK tumors) or 400 nM for SU-DHL-1 cells, which are more sensitive to the drug [15]. Here, ALK is linked to anaplastic large cell lymphoma.