COL6A3 and malignant colon neoplasm: Interestingly, high level of COL6A3 was found to be associated with poor survival of colorectal cancer patients, as revealed by the Smith Colorectal dataset [32] (Log-rank test = 7.726, p = 0.0054) (Figure 6A) and the Smith Colorectal 2 dataset [32] (Log-rank test = 5.611, p = 0.0178) (Figure 6B), suggesting that upregulated COL6A3 gene expression predicted poor prognosis of colon cancer patients.