THBS2 and malignant colon neoplasm: Among the upregulated stromal cell-enriched proteins, some proteins have been reported to be potential markers in colon cancer prognosis or tumorigenicity, such as collagen XII (COL12A1) [9], thrombospondin 2 (THBS2) [21], collagen triple helix repeat-containing protein 1 (CTHRC1) [22] and COL5A2 [23].