Besides successfully killing tumor cells, Capsaicin has been reported to have also immune-modulating properties, being able to activate DCs through the vanilloid receptor 1 (VR1) [21] Moreover, Capsaicin has given promising results in the activation of antitumor immune response also in vivo, in animal models, [22] although contradictory studies showing a negative effect of Capsaicin on DCs have also been reported [23]. This evidence concerns the gene TRPV1 and neoplasm.