EGFR and lung adenocarcinoma: To further investigate the molecular mechanisms involved in the formation of MPE in lung adenocarcinomas harboring the EGFR-L858R mutation, we first determined whether chemokine receptors were differentially expressed between H1299-EGFR-L858R and H1299-EGFR-WT cells by performing the gene expression profile GSE1172933 from the Gene Expression Omnibus (GEO) public database.