Cells were harvested 24 hours after transfection, and then the cell proliferation rates of H1299-EGFR-WT-siScramble, H1299-EGFR-WT-siCXCR4, H1299-EGFR-L858R-siScramble and H1299-EGFR-L858R-siCXCR4 lung cancer cells were analyzed. The gene discussed is EGFR; the disease is lung carcinoma.