The pooled OR from two studies including 17 pancreatic cancer patients and 45 controls was 1.04 (95% CI = 0.32–3.43, Z = 0.07, P = 0.95), indicating no correlation between smoking and hypermethylation status of CDKN2A gene (Fig. 7). Here, CDKN2A is linked to pancreatic neoplasm.