When multiple regression analyses were re-performed in 79 non-CVD patients (model 4), both plasma leptin and duration of diabetes showed tendency to associate with SDNN (β = −0.280, p = 0.062; β = −0.233, p = 0.051, respectively) and SDANN5 (β = −0.281, p = 0.066; β = −0.207, p = 0.087, respectively). This evidence concerns the gene LEP and diabetes mellitus.