Microarray data indicated that BCOX1 is significantly increased in patients with lymph node metastasis, higher Gleason score and BCR compared with patients without lymph node metastasis, BCR, and with lower Gleason score, respectively (Fig. 3g, h, i, j, k) [11, 16–18]. Here, BCR is linked to metastatic malignant neoplasm in the lymph nodes.