Using the transcription profiles of three MTX-sensitive osteosarcoma (Saos-2) cell lines and three MTX-resistant Saos-2 cell lines and analyzing the network of the differentially expressed genes (DEGs), Selga et al. have found the alteration in the expression of a number of genes, such as eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) in the MTX-resistant osteosarcomas (Saos-2) cell lines, pancreatic cancer, and erythroblastic leukemia cell lines [9]. The gene discussed is EEF1A1; the disease is osteosarcoma.