BRAF and carcinoma: In a recent analysis of CRC subtype-specific survival, colorectal tumors exhibiting a serrated phenotype marked by mutated BRAF, CIMP-positive, and MSS status, were associated with the poorest prognosis [105]; specifically, patients with these serrated cancers were more than twice as likely to die from their disease than patients with tumors exhibiting a phenotype indicative of the traditional adenoma–carcinoma sequence.