Although previous studies have not consistently found KRAS mutation and CIMP status individually to be significant indicators of prognosis, at least one recent study has found that CRC with a KRAS-mutated/CIMP-low phenotype indicative of this alternative pathway confer a significantly poorer prognosis than tumors derived from the traditional adenoma–carcinoma sequence [105, 106]. The gene discussed is KRAS; the disease is colorectal carcinoma.