Because proximal tumors are more likely to present at later stages [114, 115], this proximal distribution of serrated CRC-defining attributes could translate to a later stage at diagnosis in serrated vs. non-serrated CRC cases; however, previous studies have not consistently demonstrated differences in the distribution of stage by BRAF mutation [37, 116, 117], CIMP [36, 118], or KRAS mutation status [37, 119]. The gene discussed is BRAF; the disease is colorectal carcinoma.